Abstract
Uterine dysfunction in female companion animals is a frequent clinical concern, especially in breeding and postpartum females. Disorders such as uterine inertia, silent estrus, and pseudopregnancy affect reproductive efficiency and quality of life in pets. Hormonal therapies, although effective, may cause long-term side effects or contraindications in sensitive individuals. UTEROVAT, formulated by P S VAT PHARMA, is a homeopathic oral spray containing two scientifically validated ingredients — Caulophyllum thalictroides and Cimicifuga racemosa — that offer safe and effective support for uterine and hormonal regulation. This article outlines its pharmacodynamics, clinical indications, administration, and veterinary applications.
- Introduction
In small animal gynecology, reproductive health is influenced by a finely balanced interplay between uterine tone, endocrine regulation, and behavioral components. Common disorders such as delayed estrus, pseudopregnancy, and weak uterine contractions during labor are managed either symptomatically or with hormonal therapies. However, long-term or repeated hormonal intervention carries risks including reproductive suppression, endocrine imbalance, and contraindications in breeding animals.
UTEROVAT, developed by P S VAT PHARMA, presents a non-invasive, non-hormonal option that uses two key homeopathic ingredients with uterine-targeted actions. These actives work synergistically to restore physiological rhythm, improve uterine contractility, and stabilize hormonal imbalances — without disrupting natural reproductive cycles.
- Composition and Mechanism of Action
- Caulophyllum thalictroides
A classical homeopathic remedy known for its uterotonic and spasmolytic effects, Caulophyllum enhances coordinated uterine contractions. It is widely used in veterinary homeopathy to manage weak labor, irregular uterine contractions, uterine atony, and cycle-related disorders.
- Pharmacological Action: Stimulates smooth muscle fibers of the uterus to restore rhythmic contractions.
- Clinical Utility: Effective in cases of primary uterine inertia, delayed parturition, and post-whelping subinvolution.
- Cimicifuga racemosa (Actaea racemosa)
Cimicifuga acts centrally on the hypothalamic-pituitary-ovarian (HPO) axis and peripherally on the uterus. It regulates hormonal signaling and has mood-stabilizing properties. In veterinary practice, it is particularly useful for hormonal imbalances manifesting as behavioral disturbances, silent heat, and irregular estrous cycles.
- Pharmacological Action: Modulates neuroendocrine signaling and relaxes uterine spasms.
- Clinical Utility: Supports hormonal rhythm, reduces estrous suppression, and relieves behavioral tension associated with reproductive phases.
- Dosage Form and Pharmaceutical Advantages
UTEROVAT is presented as a 50 ml metered oral spray, designed for high compliance and rapid systemic absorption. The delivery via buccal/sublingual mucosa ensures bypass of hepatic first-pass metabolism, enhancing therapeutic onset.
Key benefits of oral spray technology:
- Fast-acting: Direct mucosal absorption for quicker effects
- Non-invasive: Stress-free administration, ideal for anxious pets
- Precise dosing: Each spray delivers a calibrated amount
- No refrigeration required: Room temperature stability for easy storage
This form is particularly suitable for pets that resist oral tablets or injectable medications.
- Therapeutic Indications
UTEROVAT is indicated for a variety of reproductive health issues in female dogs and cats, including:
- Uterine inertia (primary or early-stage): To improve contractile strength during whelping
- Postpartum subinvolution: Enhancing uterine tone after delivery
- Irregular or silent estrus: Supporting cycle normalization
- Pseudopregnancy (false pregnancy): Alleviating behavioral and hormonal symptoms such as nesting and false lactation
- Hormonal restlessness: Managing irritability or anxiety around reproductive cycles
- Reproductive tonic: As a preventive uterine support in breeding females
The dual action on both muscular and hormonal pathways makes UTEROVAT a versatile addition to reproductive management protocols.
- Dosage and Administration
UTEROVAT is administered orally, directly into the mouth or mixed with food if necessary. Dosing should be adjusted based on the animal’s size and severity of condition.
Recommended Dosage (Twice Daily):
- ✅ Small animals (cats, toy breeds): 2–3 sprays
- ✅ Medium breed dogs: 3–4 sprays
- ✅ Large breed dogs: 4–5 sprays
Duration of use: Typically 5 to 21 days, based on the clinical indication. In breeding programs or recurrent cycle issues, veterinarians may advise cyclic or seasonal use.
- Clinical Advantages
Compared to synthetic hormone-based therapies, UTEROVAT offers the following distinct clinical benefits:
- 🟢 Non-hormonal and non-steroidal
- 🟢 No adverse systemic effects
- 🟢 Safe for long-term use
- 🟢 No withdrawal period — safe during breeding and lactation
- 🟢 Improves both uterine function and hormonal behavior
- 🟢 Compliant with integrative veterinary care
It is especially useful in clinics that emphasize holistic, side-effect-free reproductive support.
- Conclusion
UTEROVAT, developed by P S VAT PHARMA, is a scientifically grounded, two-ingredient homeopathic formulation targeting the most common uterine dysfunctions in female companion animals. With the uterine-toning action of Caulophyllum thalictroides and the hormonal-regulating effect of Cimicifuga racemosa, UTEROVAT addresses the multifactorial nature of reproductive disorders in a safe and effective way.
Its oral spray delivery, high safety profile, and broad application range make it an indispensable tool for veterinarians managing female pet fertility, postpartum recovery, or estrous irregularities — particularly in patients unsuitable for hormone therapy.
About the Author:
By Akshay Prakash
Chief Executive Officer, P S VAT PHARMA